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. 2024 Dec 9;15:1466208. doi: 10.3389/fphar.2024.1466208

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Copyright © 2024 Wang, Fan, Wei, Chai, Li, Gao, Liu and Guo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cardioprotective effects of Z-LIG/CGA 7 days post-MI. (A) Representative panoramic photographs of hearts with HE staining in each group. HE staining showed different levels of inflammatory cell infiltration in the infarction area. Red scale bar: 1 mm, black scale bar: 100 μm. (B) Representative panoramic photographs of hearts with Masson’s staining in each group. Scar tissue was stained blue, and viable cardiomyocyte was stained red. Red scale bar: 1 mm, black scale bar: 100 μm. (C) Quantifies the cardiac fibrotic area in each group. (D) The ratio of the heart weight-to-body weight (HW/BW) in each group. (E) The ratio of the heart weight-to-tibia length (HW/TL) in each group. Data are expressed as mean ± SD (n = 6). #P < 0.05, ##P < 0.01, ###P < 0.001 vs. Control group. *P < 0.05, **P < 0.01, ***P < 0.001 vs. Model group. +P < 0.05, ++P < 0.01, +++P < 0.001 vs. ZC group.