Table 2.
Human scRNA-seq studies at maternal-fetal interface in recurrent pregnancy loss (RPL).
| Reference | Gestational age (weeks) | Population | Samples | Number of cells | Single cell isolation | Platform | Average reads length (bp) | Mean pair-end reads | Data repository |
|---|---|---|---|---|---|---|---|---|---|
| Lucas (36) | Peri-implantation | British | Endometrium from 3 RPL and 3 normal pregnancies | 4,580 | N/A | Drop-Seq | N/A | N/A | GEO: GSE127918 |
| Du (32) | 5-8 weeks | Chinese | Deciduae from 6 RPL and 5 normal pregnancies | 66,078 | N/A | 10× Genomics | N/A | 150 | SRA: PRJNA672658 |
| Guo (33) | 7-9 weeks | Chinese | Decidual samples from 9 RPL and 15 normal pregnancies | 18,646 | Enzyme, gradient centrifugation | 10× Genomics | N/A | 150 | GSA: CRA002181 |
| Chen (34) | 6-9 weeks | Chinese | Deciduae from 3 RPL and 3 normal pregnancies | 13,953 | Enzyme, gentleMACS, centrifugation | 10× Genomics | N/A | N/A | GEO: GSE164449 |
| Wang (37) | 6-8 weeks | Chinese | Deciduae from 3 RPL and 3 normal pregnancies | 56,758 | Enzyme, centrifugation | 10× Genomics | 98 | 40,000 | GSA: HRA000237 with BioProject: PRJCA003061 |
| Pan (35) | RPLgrou: 7.66 weeks; Control group: 7.24 weeks | Chinese | The maternal-fetal interface samples from 3 RPL and 3 normal pregnancies | 63,249 | Enzyme | NovaSeq | N/A | 150 | N/A |
| Zhu (87) | 6-12 weeks | Chinese | Decidual tissues from 46 controls and 31 RPL patients | 19,416 | Enzyme, centrifugation | Illumina HiSeq X Ten | N/A | N/A | N/A |