Table 3.
Human placental scRNA-seq studies in preeclampsia (PE).
| Reference | Gestational age (weeks) | Population | Samples | Number of cells | Single cell isolation | Platform | Average reads length (bp) | Mean pair-end reads | Data repository |
|---|---|---|---|---|---|---|---|---|---|
| Tsang (10) | Full-term, 24-33+6 weeks | Chinese | PE (n=8) vs. normal pregnancies (n=4) | 24,000 | Enzyme, centrifugation | 10× Genomics | 130 | 35,800 | EBI: EGAS00001002449 |
| Guo (46) | 31-37 weeks | Chinese | EOPE (n=7) vs. LOPE (n=6) | N/A | N/A | Python (version 3.6.6) | N/A | N/A | ArrayExpress: E-MTAB-6701, FCA7196220, FCA7196226, FCA7474064, FCA7474065, FCA7474068, FCA7511884 |
| Zhang (45) | 34-38 weeks | Chinese | PE (n=3) vs. healthy pregnancies (n=3) | 11,5181 | N/A | Illumina HiSeq X | N/A | 150 | N/A |
| Zhou (44) | 32-40 weeks | Chinese | Severe PE (n=2) vs. normal pregnancies (n=2) | 29,008 | Enzyme, centrifugation | 10× Genomics | N/A | N/A | GEO: GSE173193 |
| Yang (88) | LOPE: 34-37 weeks; normal pregnancy: more than 38 weeks | Chinese | Placenta: LOPE (n=3) vs. normal pregnancies (n=3); decidua: LOPE (n=3) vs. normal pregnancies (n=4) | N/A | Enzyme, centrifugation | Novaseq (Illumina, novaseq6000) | N/A | N/A | N/A |
| Luo (89) | Third trimester | Chinese | PE (n=2) vs. normal pregnancies (n=2) | 101,250 | N/A | BD Rhapsody and Illumina HiSeq 4000 | N/A | N/A | GSA: HRA004699 |
EOPE, early-onset PE; LOPE, late-onset PE.