TABLE 1.

Natural products isolated from L. verticillata Hance with anti-HIV activities.

Isolated compound	Separation method	Active part	Anti-HIV to HOG.R5 IC50 (μg/mL)	Cytotoxicity to HOG.R5 CC50 (μg/mL)	Selectivity index (CC50/IC50)	References
	PH	LF + TW	5.0 a	13.2 a	2.6	Zhang et al. (2001)
	PH	LF + TW	2–3 a	5.7 a	2.8–1.9	Zhang et al. (2003a)
	PH	LF + TW	7.1 a	17.5 a	2.4	Zhang et al. (2003a)
	PH	LF + TW	14.4 a	>20 a	>1	Zhang et al. (2003a)
	PH	LF + TW	4.0 a	12.4 a	3.1	Zhang et al. (2003a)
	PH	LF + TW	11.3 a	20.0 a	1.7	Zhang et al. (2003a)
	PH	LF + TW	T a	2.5–5.0 a	—	Zhang et al. (2003a)
	SC	LF + TW	34.5 a	NT a	—	Hoang et al. (2002)
	SC	LF + TW	16.4 a	23.0 a	1.4	Hoang et al. (2002)
	SC	LF + TW	I a	NT a	—	Hoang et al. (2002)
	PH	LF + TW	6.5 a	15.9 a	2.4	Zhang et al. (2003b)
	PH	LF + TW	I a	NT a	—	Zhang et al. (2003b)
	PH	LF + TW	17.4 a	NT a	—	Zhang et al. (2003b)
	PH	LF + TW	I a	NT a	—	Zhang et al. (2003b)
	PH	LF + TW	I a	NT a	—	Zhang et al. (2003b)
	PH	LF + TW	I a	NT a	—	Zhang et al. (2003b)
	PH	LF + TW	28.0 a	NT a	—	Zhang et al. (2003b)
	PH	LF + TW	I b	NT b	—	Zhang et al. (2005)
	PH	LF + TW	9.0 b	26.5 b	2.9	Zhang et al. (2005)
	PH	LF + TW	I b	NT b	—	Zhang et al. (2005)
	PH	LF + TW	14.0 b	NT b	>1	Zhang et al. (2005)
	PH	LF + TW + FB	14.0 b	NT b	—	Guan et al. (2016)
	PH	LF + TW + FB	I b	- b	—	Guan et al. (2016)

Note: PH, preparative HPLC; SC, si gel column; LF, leaves; TW, twigs; FB, flower buds; I, inactive; NT, nontoxic at 20 μg/mL; T, toxic.

^a Untreated cells served as controls.

^b 3TC (Lamivudine) was used as control compound with a IC₅₀ value of 1.2 μM in the same HOG.R5 system.