Table 1.
Key elements of MCDA.
| Pathogens evaluated | |
|---|---|
| Chikungunya virus Chlamydia trachomatisa Cytomegalovirus Dengue virus Extra-intestinal pathogenic E coli (ExPEC) Group A streptococcus (Streptococcus pyogenes) Group B streptococcus (Streptococcus agalactiae) Hepatitis C virusa Herpes simplex virus types 1 and 2 Hookworm Human immunodeficiency virus 1 (HIV-1) Influenza virus Intestinal pathogenic E coli (InPEC) |
Klebsiella pneumoniae Leishmania species Mycobacterium leprae (leprosy) Mycobacterium tuberculosis (TB) Neisseria gonorrhoeae Non-typhoidal Salmonella Norovirus Plasmodium falciparum (malaria) Respiratory syncytial virus Salmonella Paratyphi Schistosomes Shigella species Staphylococcus aureus |
| Criteria for prioritisation | |
| Scored quantitatively | Scored qualitatively |
|
Annual deaths in children under 5: Deaths attributable to the pathogen in both sexes, <5 years old Annual deaths in people older than 5: Deaths attributable to the pathogen in both sexes, ≥5 years old Yearslived withdisability (all ages): Years lived with any short-term or long-term health loss caused by the pathogen, weighted for severity |
Social and economic burden per case: Reflects individual social and economic impact such as stigma and the costs of prevention, health care, and lost productivity Disruption due to outbreaks: Reflects societal impact due to outbreaks and epidemics, including social disruption; impact on healthcare systems, trade or tourism; and the cost of containment measures Contribution to inequity: Reflects disproportionate impact on socially and economically disadvantaged groups, including women Contribution to antimicrobial resistance (AMR): Reflects the threat of resistance, based on current levels of resistance, contribution to antibiotic use, and designation as an AMR priority Unmet needs for prevention and treatment: Reflects the effectiveness and suitability of alternative measures |