Fig. 1.

Dynamics of antibody titres in the COVAXID cohort. (A) Prevailing major SARS-CoV-2 subvariants in Sweden during the study period. (B) Dynamics of Spike Wu-Hu.1 Ab titres (geometric mean with 95% CI, shaded range) for each subgroup. The vertical dotted line represents the 1-year follow-up sample timepoint. (C) Bar plots showing Spike Wu-Hu.1 Ab titres at 3, 6, 9, 12, 18 and 24 months at a study group level. Statistical tests were performed using Mann–Whitney, and Bonferroni correction for multiple comparisons, using the 24-month timepoint as reference. (D) Seroconversion rates over time in each subgroup as defined by Spike receptor-binding domain (RBD) titres ≥0.8 AU/ml. The star annotation (∗) indicates statistical significance at a p-value threshold of 0.05 (or ∗∗ for p < 0.01, ∗∗∗ for p < 0.001, ∗∗∗∗ for p < 0.0001).