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. 2024 Dec 9;15:1509658. doi: 10.3389/fimmu.2024.1509658

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Copyright © 2024 Lin, Wang, Wang, Xu, Zhang, Sun and Yuan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification of tumor cells Gene Regulatory Network. (A, B) UMAP plot visualization of all TCs based on regulator activity. Colored according to cell subtype. Pie charts showed the proportion of different tissue sources in TCs subtypes. (C) Based on the CSI matrix, three regulatory modules of TCs subtypes were identified. (D) Bar graphs illustrated the expression levels of different regulatory modules in subtypes of TCs. (E) In subtypes, the ranking of regulators in different regulation modules based on fraction of variance. (F, G) Rank for regulons in different TCs subtypes based on regulon specificity score (RSS). (H) C0 FXYD5+ TCs were highlighted in the UMAP plot (red). (I) Expression of key regulators CEBPB, ETV4, NR1H4 and XBP1 of C0 FXYD5+ TCs in all TCs.