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. 2024 Dec 17;16:2063–2082. doi: 10.2147/NSS.S485952

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© 2024 Chen et al.

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IH-induced exosomes caused behavior and cognitive deficits in mice (n=15). (A) Flow diagram of bEnd3-cell-derived exosomes intervention in mice. (B) Fluorescence images of PKH67-labelled bEnd3-cell-derived exosomes in hippocampus. Exosomes were labelled with PKH67 (green) and nuclei were stained with DAPI (blue). Magnification×200. Scale bar, 50 µm. Magnification×400. Scale bar, 20 µm. (C) Escape latency was the time that mice first climbed onto the hidden platform or first passed through the area where the platform was located. (D) The percentage of time that mice spent in the quadrant where the platform is located versus the total time. (E) The frequency of passing through the area where the platform was located. (F) The swimming trail map of mouse in the swimming pool during 60 seconds at day 6. Statistical analysis of the data was performed using one-way ANOVA (D and E), and two-way ANOVA (C) followed by Bonferroni’s multiple comparison tests, df (2, 12). *P<0.05. **P<0.01.