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. 2024 Dec 17;16:2063–2082. doi: 10.2147/NSS.S485952

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© 2024 Chen et al.

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MFN2 inhibits pyroptosis of HT22 cells (n=3). (A, B, D and E) Western blot and qRT-PCR were used to detect the expression of MFN2, GSDMD, and Caspase-1 protein and mRNA in MFN2 gene silencing or overexpression with or without IH-EXOS exposure. (C and F) ELISA was used to detect IL-1β, IL-6, IL-18, and TNF-α levels in MFN2 gene silencing or overexpression with or without IH-EXOS exposure. Statistical analysis of the data was performed using two-way ANOVA followed by Bonferroni’s multiple comparison tests, df (2, 6). *P<0.05.