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. 2024 Dec 18;17:1197–1207. doi: 10.2147/OTT.S492659

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© 2024 Wang et al.

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Knockdown of FGFR3-TACC3 suppresses proliferation in cell-derived organoids. The volume of cell-derived organoids showing the effects of FGFR3-TACC3 knockdown by Cas13a or shRNA on proliferation in RT4 cells. Knockdown of FGFR3-TACC3 decreased the volume of cell-derived organoids. The Cas13a group obviously inhibited the volume of cell-derived organoids compared with the shRNA group (A). Images of cells derived from organoid (B). Volume of cells derived from organoid. The determination of cell-derived organoid volume involved the measurement of organoid diameter (in micrometers) across distinct groups (n = 20, obtained from four independent batches). Significant results are presented as *p < 0.05, **p < 0.01, and ***p< 0.001.