Figure 7.

miR-532-3p pairs with 3′-UTR of SPARC

(A–C) Overexpression or decreased expression of miR-532-3p affected SPARC mRNA levels but did not affect the mRNA expression of other genes.

(D and E) SPARC protein levels were affected by miR-532-3p.

(F) Binding sites between the SPARC 3′UTR and miR-532-3p.

(G) Results of luciferase reporter assays. Data are represented as mean ± SD. n = 3, ∗∗p < 0.01, ∗∗∗p < 0.001, ns: no significance, 3′-UTRs 3′-untranslated regions, SPARC secreted protein acidic and rich in cysteine, NC negative control.