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. 2024 Dec 4;27(12):111437. doi: 10.1016/j.isci.2024.111437

Figure 9.

Figure 9

miR-532-3p influences cell apoptosis and cell cycle distribution

(A–C) Percentage of total apoptotic QBC939 cells (following the transfection of SPARC plasmids or control) after incubation with OXA (5 μmol/L) and 5-Fu (10 μmol/L) for 48 h.

(D–F) Percentage of total apoptotic FRH0201 cells (following the transfection of siRNA against SPARC or control, 2 μg) after incubation with OXA (20 μmol/L) and 5-Fu (80 μmol/L) for 48 h.

(G) Cell cycle distribution of QBC939 cells (following the transfection of SPARC plasmids or control) after incubation with OXA (5 μmol/L) and 5-Fu (10 μmol/L) for 48 h.

(H) Cell cycle distribution of FRH0201 (following the transfection of siRNA of SPARC or control) cells after incubation with OXA (20 μmol/L) and 5-Fu (80 μmol/L) for 48 h. Data are represented as mean ± SD. n = 3, ∗p < 0.05, ∗∗p < 0.01, ns: no significance. SPARC secreted protein acidic and rich in cysteine, OXA oxaliplatin, 5-Fu 5-fluorouracil, siRNA small interfering RNA.