Scheme 3. Late-stage functionalization of bioactive molecules.^a Standard reaction conditions: conjugated ene-yne-ketone (E/Z = 1 : 1, 0.3 mmol), Ph₃P⁺CF₂CO₂⁻ (2.0 equiv.), and PFTB (10 mol%) in CPME (3.0 mL) at 50 °C under Ar for 12 h. Isolated yields are shown.