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. 2024 Dec 4. Online ahead of print. doi: 10.1039/d4qo01808g

Scheme 1. Synthesis of CBr2I2. Conditions: (a) Boc2O; DIPEA; THF; 0 °C–r.t.; 20 h; 66%. (b) PdCl2(dppf); B2Pin2; KOAc; dioxane; 85 °C; 22 h; 98%. (c) 2; DCC; DMAP; CH2Cl2/DMF; r.t.; 16 h; 95%. (d) PdCl2(PPh3)2; KF; B(OH)3, Tol/MeOH/H2O; r.t.; 16 h; 65%. (e) (i) p-TsOH; ACN/Tol; r.t./4 h; (ii) NaNO2; KI; H2O; −15 °C to r.t.; 1 h; 62%.

Scheme 1