Skip to main content
. 2024 Dec 6;14:1433256. doi: 10.3389/fonc.2024.1433256

Figure 1.

Figure 1

Identification of RAS-MAPK pathway as a target of APR-246. (A) Protein phosphorylation changes of the 43 most common signaling proteins (using a Proteome profiler Kinase assay). SK-N-DZ cells were treated with 60 μM APR-246 for 30 min and 6 h. (B) Raw images of the Protein profiler Kinase assays for the four most deregulated proteins and their corresponding normalized fold-change values (SK-N-DZ). (C) Western blot analyses of Phospho-ERK1/2 after 0.5 h, 1 h, 2 h, 4 h, and 6 h treatment with 60 μM APR-246 in BE-2C, SK-N-DZ, and NBL-S cells.