Table 2. Effects of any exposure to intervention (regardless of duration), with and without adjustment for baseline values of outcome^*.

Outcomes	Not adjusted for baseline			Adjusted for baseline†
	OR	95% CI	P value	OR	95% CI	P value
Individuals with asthma
Start or change in treatment	1.26	0.99 to 1.60	0.064	1.29	1.02 to 1.64	0.033
Spirometry ordered	1.64	1.29 to 2.10	<0.001	1.55	1.22 to 1.97	<0.001
Individuals with COPD
Start or change in treatment	1.07	0.79 to 1.44	0.671	1.05	0.80 to 1.37	0.729
Spirometry ordered	1.53	1.17 to 2.01	0.002	1.50	1.15 to 1.96	0.003
All Individuals
New cardiovascular diagnosis	1.14	0.95 to 1.36	0.157	1.14	0.95 to 1.36	0.159
Any cardiovascular risk test	0.86	0.76 to 0.99	0.031	0.86	0.76 to 0.98	0.023
New antidepressant	1.22	0.94 to 1.58	0.127	1.18	0.92 to 1.52	0.193

^*Mixed effect logistic regression models, adjusted for randomisation stratum.

^†Also adjusted for mean clinic level baselines values of respective outcome variable.

COPD, chronic obstructive pulmonary disease.