Table 2.
Diagnostic performance of the QIAstat‐Dx‐RP2.0 compared to the BioFire‐RP2.1 multiplex panel test.
| Viruses | Pathogen | TP | FP | TN | FN | PPA (95% CI) | NPA (95% CI) | OPA | κ–Score |
| Adenovirus | 9 | 1 | 252 | 7 | 56.3 (30.6–79.2) | 99.6 (97.4–100) | 97.0 | 0.68 | |
| Bocavirus1 | 4 | 0 | 265 | 0 | 100 (39.6–100) | 100 (98.2–100) | na | na | |
| HCoV‐229E | 2 | 0 | 267 | 0 | 100 (19.8–100) | 100 (98.3–100) | 100 | 1.00 | |
| HCoV‐HKU1 | 8 | 0 | 259 | 2 | 80.0 (44.2–96.5) | 100 (98.2–100) | 99.3 | 0.89 | |
| HCoV‐NL63 | 0 | 0 | 269 | 0 | na | 100 (98.3–100) | 100 | na | |
| HCoV‐OC43 | 6 | 0 | 262 | 1 | 85.7 (42.0–99.3) | 100 98.2–100) | 99.6 | 0.92 | |
| MERS‐CoV | 0 | 0 | 269 | 0 | na | 100 (98.3–100) | 100 | na | |
| hMPV | 11 | 0 | 258 | 0 | 100 (67.9–100) | 100 (98.2–100) | 100 | 1.00 | |
| IV‐A2 | 21 | 0 | 248 | 0 | 100 (80.8–100) | 100 (98.1–100) | 100 | 1.00 | |
| IV‐A/H1‐2009 | 19 | 0 | 250 | 0 | 100 (79.1–100) | 100 (98.1–100) | 100 | 1.00 | |
| IV‐A/H1 | 0 | 0 | 269 | 0 | na | 100 (98.3–100) | 100 | na | |
| IV‐A/H3 | 2 | 0 | 267 | 0 | 100 (19.8–100) | 100 (98.3–100) | 100 | 1.00 | |
| IV‐B | 1 | 0 | 268 | 0 | 100 (5.5–100) | 100 (98.2–100) | 100 | 1.00 | |
| HPIV‐1 | 0 | 0 | 269 | 0 | na | 100 (98.3–100) | 100 | na | |
| HPIV‐2 | 1 | 1 | 267 | 0 | 100 (5.4–100) | 99.6 (97.6–100) | 99.6 | 0.67 | |
| HPIV‐3 | 2 | 0 | 267 | 0 | 100 (39.6–100) | 100 (98.3–100) | 100 | 1.00 | |
| HPIV‐4 | 6 | 1 | 262 | 0 | 100 (51.7‐100) | 99.6 (97.6–100) | 99.6 | 0.92 | |
| RSV | 28 | 0 | 236 | 5 | 84.8 (67.3–94.3) | 100 (98.0–100) | 98.1 | 0.91 | |
| HRV/HEV | 61 | 0 | 199 | 9 | 87.1 (76.5–93.6) | 100 (98.0–100) | 96.7 | 0.91 | |
| SARS‐CoV‐2 | 36 | 1 | 226 | 6 | 85.7 (70.8–94.1) | 99.6 (97.2–100) | 97.4 | 0.90 | |
| Bacteria | B. parapertussis | 0 | 0 | 269 | 0 | na | 100 (98.3–100) | 100 | na |
| B. pertussis | 0 | 1 | 268 | 0 | na | 99.6 (98.2–100) | 99.6 | na | |
| C. pneumoniae | 1 | 0 | 267 | 1 | 50.0 (2.7–97.3) | 100 (98.2–100) | 99.6 | 0.67 | |
| L. pneumophila | 0 | 0 | 269 | 0 | na | 100 (98.3–100) | 100 | na | |
| M. pneumoniae | 14 | 0 | 253 | 2 | 87.5 (60.4–97.8) | 100 (98.1–100) | 99.3 | 0.93 |
Abbreviations: FN, false negative; FP, false positive; HAdV, human adenovirus; HCoV, human coronavirus; hMPV, human metapneumovirus A and B; HPIV, human parainfluenzavirus; HRV/HEV, human rhino‐/enterovirus; IV‐A, influenzavirus A; IV‐B, influenzavirus B; k, kappa score; MERS, Middle East respiratory syndrome coronavirus; NPA, negative percent agreement; OPA, overall percent agreement; PPA, positive percent agreement; RSV, respiratory syncytial virus A and B; TN, true negative; TP, true positive.
1
HBoV is not included in the BioFire‐RP2.1 multiplex panel test.
2
BioFire‐RP2.1 multiplex panel test is reporting influenza A subtypes.