Table 5.

Predictors of clinical remission and endoscopic remission in CD patients with late UST use.

Predictors of treatment outcomes	Univariate analysis OR (95% CI)	p Value	Multivariate analysis OR (95% CI)	p Value
Clinical remission
Disease location
Ileal	Reference		Reference
Colonic	2.375 (0.345–16.357)	0.380	2.516 (0.314–20.124)	0.385
Ileocolonic	0.471 (0.198–1.118)	0.088	0.759 (0.291–1.978)	0.573
Active perianal disease	1.171 (1.072–1.405)	<0.001	1.195 (1.078–1.489)	<0.001
Body mass index	1.151 (1.013–1.308)	0.031	1.129 (0.985–1.293)	0.081
Endoscopic remission
Severe disease	3.880 (1.220–12.347)	0.022	3.880 (1.220–12.347)	0.022

Variables entered in the multivariable models before backward selection was performed included those with p < 0.1. For clinical and endoscopic remission, variables included gender, disease location, stricturing/penetrating phenotype, active perianal disease, extra-intestinal manifestations, previous intestinal resection, previous or current smoker, biologics exposure, severe disease, body mass index, and CRP/ALB.

ALB, albumin; CD, Crohn’s disease; CRP, C-reactive protein; UST, Ustekinumab.