Table 3.
Logistic analysis for exploration of risk factors of any postoperative complications of patients who underwent laparoscopic pancreatoduodenectomy
| Variables |
Univariate analysis1
|
Multivariate analysis1
|
Univariate analysis2
|
Multivariate analysis2
|
||||
|
OR (95%CI)
|
P value
|
OR (95%CI)
|
P value
|
OR (95%CI)
|
P value
|
OR (95%CI)
|
P value
|
|
| Sex | 0.766 | 0.095 | 0.528 | |||||
| Male | 1.000 | 1.000 | 1.000 | |||||
| Female | 0.957 (0.714-1.281) | 0.729 (0.502-1.057) | 0.872 (0.570-1.334) | |||||
| Age | 0.268 | 0.046 | 0.209 | |||||
| < 65 | 1.000 | 1.000 | 1.000 | |||||
| ≥ 65 | 1.173 (0.885-1.555) | 1.417 (1.006-1.998) | 1.266 (0.876-1.829) | |||||
| Pathology | 0.203 | 0.117 | ||||||
| Benign tumors | 1.000 | 1.000 | ||||||
| Malignant tumors | 1.239 (0.891-1.723) | 1.411 (0.918-2.169) | ||||||
| ECOG score | 0.245 | 0.010 | 0.107 | |||||
| 0-1 | 1.000 | 1.000 | 1.000 | |||||
| 2 | 1.339 (0.819-2.190) | 2.005 (1.179-3.410) | 1.637 (0.898-2.982) | |||||
| Preoperative biliary drainage | 0.047 | 0.419 | ||||||
| Yes | 1.000 | 1.000 | 0.001 | 1.000 | ||||
| No | 1.488 (1.005-2.205) | 2.160 (1.387-3.364) | 1.227 (0.747-2.017) | |||||
| Hypertension | 0.510 | 0.802 | ||||||
| No | 1.000 | 1.000 | ||||||
| Yes | 1.110 (0.813-1.516) | 1.051 (0.714-1.545) | ||||||
| Diabetes mellitus | 0.568 | 0.012 | 0.031 | |||||
| No | 1.000 | 1.000 | 1.000 | |||||
| Yes | 1.107 (0.781-1.569) | 1.887 (1.150-3.096) | 1.773 (1.054-2.983) | |||||
| Pancreatitis | 0.194 | 0.633 | ||||||
| No | 1.000 | 1.000 | ||||||
| Yes | 1.402 (0.842-2.335) | 1.159 (0.633-2.119) | ||||||
| Abdominal surgery history | 0.276 | 0.170 | ||||||
| No | 1.000 | 1.000 | ||||||
| Yes | 1.400(0.765-2.564) | 1.596 (0.818-3.144) | ||||||
| Smoking | 0.511 | 0.253 | ||||||
| No | 1.000 | 1.000 | ||||||
| Yes | 1.103 (0.824-1.476) | 1.228 (0.863-1.747) | ||||||
| Alcohol consumption | 0.258 | 0.272 | ||||||
| No | 1.000 | 1.000 | ||||||
| Yes | 1.188 (0.881-1.602) | 1.224 (0.854-1.756) | ||||||
| BMI | 0.115 | 0.271 | ||||||
| < 25 | 1.000 | 1.000 | ||||||
| ≥ 25 | 1.259 (0.945-1.676) | 1.222 (0.855-1.747) | ||||||
| Operation time | 1.001 (0.999-1.002) | 0.484 | 1.001 (0.999-1.003) | 0.408 | ||||
| Blood loss | 1.000 (0.999-1.001) | 0.956 | 1.000 (0.998-1.001) | 0.533 | ||||
| Intraoperative blood transfusion | 0.004 | 0.890 | 0.096 | 0.660 | ||||
| No | 1.000 | 1.000 | 1.000 | 1.000 | ||||
| Yes | 1.572 (1.154-2.140) | 1.025 (0.722-1.455) | 1.364 (0.946-1.966) | 1.102 (0.715-1.700) | ||||
| ASA score | 0.475 | 0.496 | ||||||
| II | 1.000 | 1.000 | ||||||
| III | 1.111 (0.833-1.481) | 1.130 (0.795-1.606) | ||||||
| RDW | < 0.001 | < 0.001 | < 0.001 | < 0.001 | ||||
| < 15.4 | 1.000 | 1.000 | 1.000 | 1.000 | ||||
| ≥ 15.4 | 3.537 (2.553-4.900) | 2.973 (2.032-4.350) | 3.603 (2.525-5.141) | 3.138 (2.042-4.824) | ||||
| Hemoglobin, g/L | 0.212 | 0.024 | 0.426 | |||||
| < 115 | 1.000 | 1.000 | 1.000 | |||||
| ≥ 115 | 0.813 (0.588-1.125) | 0.647 (0.443-0.944) | 0.823 (0.509-1.331) | |||||
| Leucocytes, 109/L | 0.250 | 0.047 | 0.533 | |||||
| < 9.5 | 1.000 | 1.000 | 1.000 | |||||
| ≥ 9.5 | 1.308 (0.827-2.068) | 1.675 (1.006-2.789) | 1.198 (0.679-2.113) | |||||
| Platelet, 109/L | 0.003 | 0.093 | 0.996 | |||||
| < 350 | 1.000 | 1.000 | 1.000 | |||||
| ≥ 350 | 1.894 (1.247-2.878) | 1.493 (0.935-2.383) | 1.001 (0.605-1.657) | |||||
| Lymphocyte, 109/L | 0.225 | 0.612 | ||||||
| < 3.2 | 1.000 | 1.000 | ||||||
| ≥ 3.2 | 2.771 (0.534-14.368) | 1.532 (0.295-7.968) | ||||||
| AST, U/L | 0.002 | 0.190 | 0.016 | 0.649 | ||||
| < 35 | 1.000 | 1.000 | 1.000 | 1.000 | ||||
| ≥ 35 | 1.610 (1.191-2.177) | 1.617 (0.788-3.320) | 1.618 (1.094-2.393) | 1.229 (0.505-2.991) | ||||
| ALT, U/L | 0.042 | 0.731 | 0.035 | 0.651 | ||||
| < 40 | 1.000 | 1.000 | 1.000 | 1.000 | ||||
| ≥ 40 | 1.363 (1.011-1.837) | 1.140 (0.541-2.403) | 1.516 (1.031-2.231) | 1.226 (0.508-2.959) | ||||
| GGT, U/L | 0.004 | 0.186 | 0.006 | 0.454 | ||||
| < 45 | 1.000 | 1.000 | 1.000 | 1.000 | ||||
| ≥ 45 | 1.601 (1.166-2.199) | 1.511 (0.820-2.785) | 1.809 (1.182-2.770) | 1.335 (0.626-2.848) | ||||
| ALP, U/L | 0.058 | 0.017 | 0.220 | |||||
| < 140 | 1.000 | 1.000 | 1.000 | |||||
| ≥ 140 | 1.330 (0.990-1.787) | 1.979 (1.130-3.464) | 1.262 (0.871-1.829) | |||||
| TBIL, umol/L | 0.002 | 0.624 | < 0.001 | 0.152 | ||||
| < 235 | 1.000 | 1.000 | 1.000 | 1.000 | ||||
| ≥ 235 | 1.605 (1.191-2.163) | 1.099 (0.754-1.601) | 2.172 (1.531-3.082) | 1.551 (0.850-2.829) | ||||
| Albumin, g/L | < 0.001 | 0.012 | < 0.001 | 0.149 | ||||
| ≥ 35 | 1.000 | 1.000 | 1.000 | 1.000 | ||||
| < 35 | 2.598 (1.794-3.764) | 1.735 (1.130-2.662) | 2.628 (1.781-3.879) | 1.417 (0.883-2.274) | ||||
| CRP, mg/L | 0.002 | 0.197 | 0.001 | 0.205 | ||||
| < 10 | 1.000 | 1.000 | 1.000 | 1.000 | ||||
| ≥ 10 | 1.599 (1.180-2.168) | 1.265 (0.885-1.807) | 1.797 (1.260-2.564) | 1.308 (0.863-1.983) | ||||
| PT, second | 0.760 | 0.277 | ||||||
| < 14 | 1.000 | 1.000 | ||||||
| ≥ 14 | 0.928 (0.574-1.499) | 0.736 (0.424-1.278) | ||||||
1
Any morbidity, Clavien-Dino classification grade I or higher.
2
Severe morbidity, Clavien-Dino classification grade IIIa or higher.
OR: Odds ratio; CI: Confidence interval; ECOG: Eastern Cooperative Oncology Group; BMI: Body mass index; ASA: American Society of Anesthesiologists; RDW: Red blood cell distribution width; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; ALP: Alkaline phosphatase; GGT: γ-glutamyl transferase; TBIL: Total bilirubin; CRP: C-reactive protein; PT: Prothrombin time.