Fig. 4.

miR-138-5p was a target miRNA of HCP5. A) Bioinformatics tools confirmed the binding site between HCP5 and miR-138-5p. B) Luciferase reporter analysis was employed to confirm the relationship between miR-138-5p and HCP5. C) Serum miR-138-5p levels in neonatal sepsis (NS) patients and controls (neonatal without sepsis but diagnosed with respiratory tract infection or pneumonia). D) Pearson correlation coefficient was employed to assess the correlation between miR-138-5p and HCP5. E) miR- 138-5p levels after transfection of HCP5 overexpression plasmid in LPS-inducible RAW264.7. ***p < 0.001 vs. controls or mimic NC; ##p < 0.01 vs. LPS + pcDNA3.1