Table 5.

Mediation analysis for serum vitamin D, SII, and disease

	ACME				ADE				Total effect				Proportion mediated
	Estimate	95% CI lower	95% CI upper	P	Estimate	95% CI lower	95% CI upper	P	Estimate	95% CI lower	95% CI upper	P	Estimate	95% CI lower	95% CI upper	P
Cancer
	-0.00000082	-0.0000035	0	0.39	0.000249	0.000164	0	<0.001	0.000249	0.000164	0	<0.001	-0.00331	-0.0147	0.01	0.39
CHD
	0.000000266	-0.000000722	0	0.64	-0.000191	-0.000334	0	<0.001	-0.00019	-0.000334	0	<0.001	-0.0014	-0.0122	0	0.64
Hypertension
	-0.00000309	-0.0000124	0	0.45	0.000382	0.000197	0	<0.001	0.000379	0.000196	0	<0.001	-0.00817	-0.0409	0.01	0.45
Diabetes
	-0.000000978	-0.0000042	0	0.44	0.00018	0.0000366	0	0.02	0.000179	0.0000339	0	0.02	-0.00545	-0.035	0.02	0.46
All-cause mortality	-0.1371	-0.2049	-0.0841	<0.001	5.6844	3.7518	7.9896	<0.001	5.5471	3.6065	7.8438	<0.001	-0.0247	-0.044	-0.0139	<0.001
CVD mortality	-0.6912	-1.2491	-0.3335	<0.001	39.456	17.6415	70.0899	<0.001	38.7647	17.052	69.2018	<0.001	-0.0173	-0.0408	-0.0087	<0.001
Cancer mortality	-0.3667	-0.6381	-0.1824	<0.001	6.3073	-4.3436	16.6769	0.27	5.9407	-4.8876	16.3519	0.25	-0.0436	-0.6791	0.4479	0.27