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. 2024 Dec 19;11:2493–2504. doi: 10.2147/JHC.S500084

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© 2024 Liu et al.

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Mechanisms of sorafenib resistance across Keap1-Nrf2 system and ETS1-miR-23a-3p-ACSL4 pathway.

Abbreviations: Keap1, kelch-like ECH-associated protein 1; NRF2, nuclear factor erythroid 2-related factor 2; ETS1, ETS oncogene 1; ACSL4, acyl-CoA synthetase long-chain family member 4; ABCC5, ATP-binding cassette transporter C5; MT-1G1, metallothionein 1G; GPX4, glutathione peroxidase 4; GSH, glutathione; ROS, reactive oxygen species.