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. 2024 Dec 23;30:269. doi: 10.1186/s10020-024-01047-8

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — ADAM19 expression in skin tissues of SSc patients from GEO datasets. (a) Volcano plots displaying ADAM19 and fibrosis-related genes (ACTA2, COL1A1, COL1A2, and FN1) expression in SSc skin GEO datasets (GSE130955, GSE58095, GSE181549). (b) Fold change ratio for ADAM19 and fibrosis-related genes (ACTA2, COL1A1, COL1A2, and FN1) in SSc skin GEO datasets (GSE130955, GSE58095, GSE181549). (c) Correlation between ADAM19 expression and fibrosis-related genes (ACTA2, COL1A1, COL1A2, and FN1) expression in SSc patients (GSE181549). (d) ADAM19 gene expression levels in skin tissues of SSc patients with negative antibody, and positive for ATA, ACA, and ARA (GSE181549). (e) ADAM19 gene expression levels in skin tissues of SSc patients with different local skin scores (GSE130955). (f) Correlation between ADAM19 expression and mRSS in SSc patients (GSE181549). (g) Correlation between ADAM19 expression and STPR in SSc patients (GSE181549). (h) Correlation between ADAM19 expression and disease duration (years) in SSc patients (GSE181549). SSc, systemic sclerosis; HC, healthy controls; mRSS, modified Rodnan Skin Score; STPR, skin thickness progression rate; ATA, antibodies to DNA topoisomerase I; ARA, antibodies to RNA polymerases; ACA, antibodies to centromere; red color, up-regulated genes; blue color, down-regulated genes. Data are represented as mean ± SEM. **, P < 0.01. ****, P < 0.0001