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. 2024 Dec 23;30:269. doi: 10.1186/s10020-024-01047-8

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — ADAM19 expression in skin tissues of SSc patients and HOCl-induced experimental models of fibrosis. (a) Expression levels of the ADAM19 protein in skin tissues of HC, SSc patients, PBS, and HOCl induced fibrosis mouse model. (b) Expression levels of the ADAM19 and fibrosis-related genes (ACTA2, COL1A1, COL1A2, and FN1) mRNA in skin tissues of PBS and HOCl-induced fibrosis mouse model. (c) Expression levels of the ADAM19 and fibrosis-related genes (ACTA2, COL1A1, COL1A2, and FN1) mRNA in isolated primary dermal fibroblasts of HC and SSc patients. (d) Expression levels of the ADAM19 and ACTA2 protein in isolated primary dermal fibroblasts of HC and SSc patients. SSc, systemic sclerosis; HC, healthy controls; HOCl, hypochlorous acid; PBS, phosphate buffer saline. Data are represented as mean ± SEM. *, P < 0.05, **, P < 0.01. ****, P < 0.0001