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. 2024 Dec 23;30:269. doi: 10.1186/s10020-024-01047-8

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Suppression of ADAM19 expression inhibited the TGF-β induced fibrosis. (a) mRNA expression of ADAM19 and fibrosis-related genes, including ACTA2, COL1A1, and FN1 in human primary dermal fibroblasts isolated from HC incubated with TGF-β (10ng/ml) 48 h. (b) Protein levels of ADAM19 and ACTA2 in human primary dermal fibroblasts isolated from HC incubated with TGF-β (10ng/ml) 48 h. (c) mRNA expression of ADAM19, COL1A1, and ACTA2 in human primary dermal fibroblasts isolated from HC transfected with negative control siRNA and ADAM19 siRNA with or without TGF-β (10ng/ml) stimulation for 48 h. (d) Protein expression of ACTA2 in human primary dermal fibroblasts isolated from HC transfected with negative control siRNA and ADAM19 siRNA with or without TGF-β (10ng/ml) stimulation for 48 h. HC, healthy controls. *, P < 0.05, **, P < 0.01. ***, P < 0.001