Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Dec 23;30:269. doi: 10.1186/s10020-024-01047-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 4 — Knockdown of ADAM19 inhibited collagen formation and fibroblast activation. (a) Volcano plot of different expression genes (DEGs) between SI ADAM19 TGF-β and SI NC TGF-β. (b) Heatmap displaying ADAM19 and collagen genes expression in human primary dermal fibroblasts isolated from HC transfected with negative control siRNA and ADAM19 siRNA with or without TGF-β (10ng/ml) stimulation for 48 h. (c) GSEA between SI ADAM19 TGF-β and SI NC TGF-β. (d) Enrichment scores of GSEA related to fibroblast activation and fibrosis in Si NC TGF-β vs. Si NC NT and Si ADAM19 TGF-β vs. Si NC TGF-β. HC, healthy controls