Figure 1.

Heterogeneity and evolution of epithelial cells in OC

(A) Pseudo-time analysis of OC epithelial cells inferred by Monocle2. Each data point corresponds to a single cell. The colors of the points represent different tissue types. M: malignant, N: normal.

(B) The cell proportion of epithelial cells of ovarium tumor, normal fallopian tube and ovarium on the pseudo-time trajectory.

(C) UMAP plot with cells colored according to tissue origin.

(D) UMAP plot with epithelial cells colored according to molecular clusters.

(E) Pseudo-time analysis of OC epithelial cells inferred by Monocle2. Each data point corresponds to a single cell. The colors of the data points represent OC epithelial cell subtypes.

(F) Proportion of cells in cluster Epi1, Epi2, Epi3 on the pseudo-time trajectory.

(G) Heat maps show the GSVA scores of cancer-related function gene sets for module1 and module3.

(H) The differentially expressed genes (rows) along the pseudo-time (columns) in OC epithelial cells.

(I) GO enrichment result of pseudo-time variable gene clusters.