Figure 2.

FTSEC3 resembles OC epithelial cell signatures and functions

(A) UMAP plot of fallopian tube epithelial cells sub clusters.

(B) Expression of classic marker genes in secretory epithelial cells and ciliated epithelial cells within the fallopian tube epithelial subgroups.

(C) Heatmap of top-ranking marker genes expression in different fallopian tube epithelial cell sub clusters. In this and all further heatmaps depicting marker genes, colors indicate row-wise scaled gene expression, with a mean of 0 and an SD of 1 (Z scores).

(D) Sankey diagram to visualize fallopian tube epithelial cell subtype projection. The number represents the number of cells (k = ∗1000).

(E) Pseudo-time analysis of fallopian tube epithelial cells inferred by Monocle2. The colors of the data points represent pseudo time (top). Position of FTSEC3 along the fallopian tube epithelial cell pseudotime trajectory (bottom).

(F) Bubble plots showing the expression of selected marker genes in fallopian tube epithelial cell sub cluster.

(G) The differentially expressed genes (rows) along the pseudo-time (columns) in fallopian tube epithelial cells.

(H) GO enrichment result of pseudo-time variable gene cluster 4.