Figure 3.

Endothelial cell heterogeneity and evolution in OC

(A) UMAP plot of endothelial cell sub clusters.

(B) Bubble plot showing differentially enriched GO terms in each endothelial cell sub cluster.

(C) UMAP plots of the distribution of endothelial cell sub cluster in three tissue types.

(D) Bar plot shows the proportion of different endothelial cell sub clusters in each tissue.

(E) The fractions of four endothelial cell sub clusters between fallopian tube, normal ovarium and OC tissues in OC bulk RNA-seq (GSE223426). Comparisons of cellular proportions between fallopian tube and ovarian tumor tissues for each endothelial cell sub cluster were performed using Student’s t test.

∗, p < 0.05; ∗∗, p < 0.01; ∗∗∗, p < 0.001, ∗∗∗∗, p < 0.0001. Data are represented as median with 25% and 75% percentile.