Skip to main content
. 2024 Nov 16;35(4):102397. doi: 10.1016/j.omtn.2024.102397

Figure 1.

Figure 1

Sharp CHD6 peaks in the C4-2 cell line

(A) Density of CHD6 in the housekeeping (HK) genes ANDP and GOLGA5 and the oncogenes (OGs) FGFR3 and CBX8. (B) Definition of genes with sharp and broad CHD6 peaks. (C) Heatmap of CHD6. Each row represents a gene region from −1 to +1 kb with respect to the gene. Top: the top 1,000 sharp CHD6 peaks; center: the top 1,000 broad CHD6 peaks; bottom: 1,000 random genes. (D) Average ChIP-seq signal value of CHD6 plotted around groups. (E) KEGG pathway enrichment of genes with sharp, broad, and control peaks. (F) Enrichment p values (y axis) of HK genes, OGs, and tumor suppressor genes (TSGs) in the different groups. (G) The percentage of gene expression. (H) Expression levels of the HK genes ANDP and GOLGA5 in tumor and normal cells. For (F), p values determined using Fisher's exact test. For (G), p values determined using one-tailed Wilcoxon test. ∗p < 0.05; ∗∗p <0.01; ∗∗∗p < 0.001.