Table 1.
Basic information of included literature.
| Number of cases |
Age |
Sex (male/female) |
GPM detection methods | Locus |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| First author | Year | Country | Ethnicity | Total number of cases | RA group | CT group | RA group | CT group | RA group | CT group | ||
| Emonts M [18] | 2011 | Netherlands | Mixed | 839 | 376 | 463 | 59.3±13.7 | 59.3±13.7 | 99/277 | 233/230 | SBE | rs1800795(G-174C) |
| Arman A [19] | 2012 | Türkiye | Caucasus | 425 | 178 | 247 | 53.12±12.7 | 54.3±11.8 | 29/149 | 87/160 | PCR-RFLP | rs1800795(G-174C) |
| Chen J [20] | 2021 | China | Asia | 1002 | 508 | 494 | 54.34±12.01 | 54.03±8.83 | 134/374 | 124/370 | SBE | rs1800796(G-572C) |
| Dar SA [21] | 2017 | India | Southeast Asia | 114 | 34 | 80 | 51.39±2.27 | 36±2.9 | 15/19 | 32/48 | PCR-SSP | rs1800795(G-174C) |
| Li X [22] | 2014 | China | Asia | 1550 | 752 | 798 | 52.3±16.3 | 52.1±17.1 | 398/354 | 431/367 | PCR-RFLP | rs1800795(G-174C) |
| Li F [23] | 2014 | China | Asia | 587 | 256 | 331 | 50.26±12.86 | 48.08±13.92 | 60/196 | 92/239 | PCR-HRM | rs1800795(G-174C, rs1800796(G-572C), rs1800797(G-597A) |
| Shafia S [24] | 2014 | India | Asia | 350 | 150 | 200 | Unreported | Unreported | 19/131 | 27/173 | PCR-RFLP | rs1800795(G-174C) |
| You CG [25] | 2013 | China | Asia | 825 | 452 | 373 | 47.08±15.36 | 47.35±14.37 | 104/348 | 102/271 | PCR-HRM | rs1800797(G-597A),rs1800796(G-572C), rs1800795(G-174C) |
| Trajkov D [26] | 2009 | Macedonia | Europe | 386 | 85 | 301 | Unreported | Unreported | Unreported | Unreported | PCR-SSP | rs1800795(G-174C) |
| Palomino-Morales R [27] | 2009 | Spain | Europe | 537 | 311 | 226 | Unreported | Unreported | 83/228 | Unreported | TaqMan | rs1800795(G-174C) |
| Panoulas VF [28] | 2009 | England | Europe | 805 | 383 | 422 | Unreported | Unreported | Unreported | Unreported | Real-time PCR | rs1800795(G-174C) |
| Huang XZ [29] | 2007 | China | Asia | 288 | 120 | 168 | 48.48±14.98 | 45.18±8.11 | 20/100 | 67/101 | PCR-SSP | rs1800795(G-174C), rs1800796(G-572C) |
| Pawlik A [30] | 2005 | Poland | Europe | 203 | 98 | 105 | 48.5 | Unreported | 37/61 | Unreported | PCR-RFLP | rs1800795(G-174C) |
| Pascual M [31] | 2000 | Spain | Europe | 320 | 163 | 157 | 50.7±14 | Unreported | Unreported | Unreported | PCR-RFLP | rs1800795(G-174C) |
| Dahlqvist SR [32] | 2002 | Sweden | Europe | 440 | 257 | 183 | 62±12.9 | Unreported | 70/187 | Unreported | PCR-SSP | rs1800795(G-174C) |
| Amr K [33] | 2016 | Egypt | Southeast Asia | 198 | 99 | 99 | Unreported | Unreported | 9/90 | 41/58 | PCR-SSP | rs1800795(G-174C), rs1800796(G-572C) |
| Ad’hiah AH [34] | 2018 | Iraq | Southeast Asia | 96 | 51 | 45 | 44.9±10.7 | 41.3±8.7 | 22/29 | 15/30 | PCR-RFLP | rs1800796(G-572C), |
| Yucel B [35] | 2020 | Türkiye | Caucasus | 145 | 49 | 96 | 52±12 | Unreported | Unreported | Unreported | PCR-SSP | rs1800795(G-174C), |
| Nisar H [36] | 2021 | Pakistan | Southeast Asia | 315 | 150 | 165 | 43.53±11.11 | Unreported | 31/119 | Unreported | TaqMan | rs1800795(G-174C) |
| Zavaleta‐Muñiz SA [37] | 2016 | Mexico | Mixed | 239 | 137 | 102 | 50±9 | 48±10 | 2/135 | 6/96 | PCR-RFLP | rs1800795(G-174C) |
| Melo TS [38] | 1992 | Brazil | Mixed | 108 | 70 | 38 | 50.9±11.4 | 52.3±12.2 | Unreported | Unreported | TaqMan | rs1800795(G-174C) |
RA: rheumatoid arthritis; PCR: polymerase chain reaction; SBE: single base extension; RFLP: restriction fragment length polymorphism; SSP: sequence specific primers.