Table 5.
Correlation between IL-6 gene rs1800795(G-174C) genotype (GG) and RA across different ethnicities.
| Ethnicity | Number of studies included | Sample size | RA group(n/total) | CG (n/total) | Heterogeneity (I2) | OR [95%CI] | P |
|---|---|---|---|---|---|---|---|
| Asian | 4 | 2775 | 1079/1278 | 1447/1497 | 93 % | 0.17 [0.03, 0.83] | 0.03 |
| European | 7 | 3516 | 990/1749 | 964/1767 | 0 | 0.95 [0.81, 1.11] | 0.50 |
| Caucasian | 2 | 570 | 114/227 | 173/343 | 48 % | 0.93 [0.66,1.31] | 0.69 |
| Southeast Asian | 3 | 627 | 149/283 | 150/344 | 98 % | 1.19 [0.07,20.23] | 0.90 |
| Mixed | 3 | 1186 | 290/583 | 244/603 | 0 | 1.29 [1.01, 1.65] | 0.04 |