Fig. 2.

Differential gene expression analysis. (A) Clustered heatmap represents transcriptome data collected from saliva samples of both healthy subjects and Black female children with OSA. (B) Differential gene expression in children with OSA compared to healthy subjects. The statistical threshold of p ≤ 0.01 with a minimum two-fold difference was used to identify significantly up- and down-regulated genes. (C) Heatmap of significantly altered genes in children with OSA, and associated fold change compared to healthy subjects. (D) Gene Set Enrichment Analysis (GSEA) of regulatory targets associated with differential gene expression. Significantly associated targets with p ≤ 0.01 are shown. (E) GSEA of hallmark pathways associated with differential gene expression. Enriched GSEA hallmark pathways with p ≤ 0.01 are displayed.