Fig. 3.

Differential methylation analysis. (A) Differentially hyper- and hypo-methylated regions across the chromosomes of Black female children with OSA, compared to matched healthy subjects. To identify differential methylated regions, a threshold of q ≤ 0.01 and a minimum methylation difference of 25 % were employed. (B) Genes that exhibit differential gene expression (p ≤ 0.01 with a minimum two-fold difference) and differential methylation (q ≤ 0.01 with a minimum of 25 % difference) within a 5000 bases (proximal) of their TSS. (C) MSigDB enrichment analysis of genes significantly differentially expressed and methylated within 200,000 bases (distal) of their TSS.