Fig.8.

SGC-PIKFYVE-1 does not induce adverse effects in female and male naïve mice. Effect of a single intraperitoneal (IP) injection of SGC-PIKFYVE-1 (30 mg/kg) or vehicle (DMSO 30 %) on (A) mechanical, (B) cold sensitivity and (C) motor coordination in male naïve mice, was measured 1 h post injection (n = 8 mice). Mechanical sensitivity was assessed using Von Frey filaments with the up-down method. Cold sensitivity was measured by applying an acetone drop to the hind paw, and motor coordination was evaluated using the rotarod test. Administration of SGC-PIKFYVE-1 or vehicle did not induce changes on (D) mechanical, (E) cold sensitivity and (F) motor coordination in female naïve mice motor impairments in male mice. Effect of SGC-PIKFYVE-1 injection (30 mg/kg) was measured 2 h post injection (n = 8 mice). All panels were compared using a Student’s t-test.