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Inflammasomes in Pyroptosis. NLRP3, AIM2, Pyrin, NLRC4, and NLRP1 inflammasomes activate caspase-1 and caspase-4/5/11, which cleave GSDMD. This releases its N-terminal domain to form membrane pores, initiating pyroptosis. Additionally, caspase-1 converts pro-IL-1β to IL-1β, enhancing inflammation, while ATP via P2X7 receptors facilitates this process.
