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. 2024 Dec 20;9(24):e182844. doi: 10.1172/jci.insight.182844

Figure 5. Intercellular communication in the skin is shifted toward an oral like state by PITX1.

Figure 5

(A) Circos plot showing the top 20 PITX1+ skin-enriched L-R interactions predicted by MultiNIcheNet between cell types of the skin. Control (n = 8) and PITX1+ (n = 8). Genes constituting predicted signaling pairs are listed on outside of plot. (B) Representative Xenium of male control skin (n = 3) and PITX1+ skin (n = 4) of indicated L-R pairs (arrows in A) highlighting Hedgehog (Hh), CCL3, and IL-1β signaling. Dashed boxes show inset area. Transcripts indicated are represented by colored dots. Scale bar = 100 μm; inset scale bar = 25 μm. (C) Circos plot showing the top 20 buccal mucosa–enriched L-R interactions over control skin predicted by MultiNIcheNet. Buccal mucosa (n = 7). (D) Representative Xenium of male control skin, PITX1+ skin, and buccal mucosa (N = 7) of indicated L-R pairs (arrows in C) highlighting expression of desmosomal cadherins and WNT and IGF1 signaling pathways. Dashed boxes show inset area. Transcripts indicated are represented by colored dots. Scale bar = 100 μm; inset scale bar = 25 μm.