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. 2005 Jun 17;102(26):9388–9393. doi: 10.1073/pnas.0409641102

Fig. 3.

Fig. 3.

Ongoing GABAA receptor-dependent release of endocannabinoids in vitro.(A) The amplitude of pharmacologically isolated GABA PSCs (WC, whole-cell recording) was increased after application of AM251 (3 μM) in a PC (P3, Upper, first image from left) and in a stratum radiatum IN (P3, Lower, first image from left). Note the appearance of large-amplitude GABA PSCs in the presence of AM251 and of spontaneous pure GABAA receptor-mediated bursts of activity (traces 1 and 2, shown on a faster time scale). On the far right are summaries of the effect of AM251 on GABA PSC amplitude in PCs and INs. (B) The frequency and amplitude of GABA PSCs was decreased after AM404 (10 μM) in a P3 PC (Top) and in a P2 IN (Middle). The graphs on the far right show a summary of the effects of AM404 on GABA PSC frequency and amplitude in PCs and INs. The spontaneous firing frequency of INs was decreased the presence of AM404 (P2; CA, cell-attached recording; Bottom). On the right is a summary of the effect of AM404 on IN spontaneous firing frequency.