Table 1. Maternal characteristics.
Preeclampsia risks. Multiparous, 2nd pregnancy and over.
| //////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////// Maternal characteristics = > /////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////// |
Controls: Multiparous with same father N = 50,782 (%) |
Multiparous with NEW father for the index pregnancy N = 2790 (%) |
OR [95% CI] |
P value |
/////////////////////////////// /////////////////////////////// /////////////////////////////// Preeclampsia risks = > ////////////////////////////////////////////////////////////// ////////////////////////////// |
Controls: Multiparous with same father N = 50,782 (%) |
Multiparous with NEW father for the index pregnancy N = 2790 (%) |
OR [95% CI] |
P value |
|---|---|---|---|---|---|---|---|---|---|
| Maternal age (years: mean ± sd) | 30.0 ± 6.03 | 31.2 ± 6.5 | < .0.0001 | Incidence preeclampsia (%) | 1049 (2.1) |
186 (6.7) |
3.39 {2.9–4.0 |
< .0.0001 | |
| Gravidity ± sd | 3.7 ± 1.9 | 4.3 ± 2.1 | < .0.0001 |
Incidence EOP (%)
< 34 weeks |
326 (0.7) |
63 (2.4) |
3.7 [2.8–4.9] |
< .0.0001 | |
| Parity ± sd | 2.0 ± 1.5 | 2.3 ± 1.6 | < .0.0001 |
Incidence LOP (%)
≥ 34 weeks |
723 (1.4) |
123 (4.5) |
3.25 [2.7–4.0] |
< .0.0001 | |
| Adolescents < 18 years | 305 (0.6) |
22 (0.8) |
1.32 [0.9–2.0] |
0.21 | History of elective abortion | 10,040 (19.8) |
813 (29.1) |
1.67 [‘1.5–1.8] |
< .0.0001 |
| Age ≥ 35 years | 12,562 (24.7) |
950 (34.1) |
1.57 [1.45–1.7] |
< .0.0001 | History of miscarriage | 12,143 [23.9] |
764 (27.4) |
1.2 [1.1–1.3] |
< .0.0001 |
| Grand multiparas (≥ 5) | 6404 (12.6) |
500 (17.9) |
1.51 [1.4–1.7] |
< .0.0001 |
History of previous
preeclampsia |
825 (1.6) |
67 (2.4) |
1.5 [1.2–1.9] |
< .0.0001 |
|
Education 10th grade
or over |
26,606 (55.0) |
1413 (51.9) |
0.88 [0.82–0.95] |
0.002 | Previous birth of an SGA newborn | 476 (0.9) |
57 (2.0) |
2.2 [1.7–2.9] |
< .0.0001 |
| Living single | 15,009 (29.8) |
1857 (66.7) |
4.7 [4.4–5.1] |
< .0.0001 |
SGA < 10th percentile | 4162 (8.3) |
361 [13.3] |
1.7 [1.5–1.9] |
< .0.0001 |
| BMI kg/m2 (mean ± sd) | 25.9 ± 6.5 | 25.8 ± 6.4 | 0.47 |
Low birhweight
< 2500g |
2216 (4.7) |
574 (9.6) |
2.2 [2.0–2.4] |
< .0.0001 | |
| Obesity ≥ 30 kg/m 2 | 11,289 /48,538 (23.3) |
611/2667 (22.9) |
1.33 [0.89–1.1] |
0.67 |
Intervals between pregnancies (years)
- Mean ± SD - Median |
4.3 ± 2.8 3.7 |
5.9 ± 3.7 5.2 |
< .0.0001 < .0.0001 |
|
| Smoking | 6785 (13.4) |
664 (23.8) |
2.0 [1.85–2.2] |
< .0.0001 |
EOP: early onset preeclampsia. LOP: late onset preeclampsia SGA: small for gestational age (< 10th percentile Reunion curve)