Table 1.

Types of lipid-lowering drugs, compounds, and gene targets.

Primary lipid modulation	Gene	Chromosome	Base pair (GRCh37)	Drug-target	Mechanism of action	SNP	Examples of drugs
LDL-C (decreasing)	HMGCR	5	74632993–74657941	HMG-CoA reductase	HMGCR inhibition	7	Statins
	PCSK9	1	55505221–55530525	Proprotein convertase subtilisin/kexin type 9	PCSK9 inhibition	12	Evolocumab, alirocumab
	APOB	2	21224301–21266945	Apolipoprotein B-100	APOB inhibition	20	Mipomersen
	NPC1L1	7	44552134–44580929	Niemann–Pick C1-like 1 protein	NPC1L1 inhibition	3	Ezetimibe
TG (decreasing)	PPARA	22	46546429–46639653	Peroxisome proliferator-activated receptor alpha	PPARA enhancement	0	Fibrates
	LPL	8	19796764–19824770	Lipoprotein lipase	LPL activation	24	Ibrolipim (investigational)
	ANGPTL3	1	63063191–63071984	Angiopoietin-like 3	ANGPTL3 inhibition	4	Evinacumab (investigational)
	APOC3	11	116700623–116703788	Apolipoprotein C3	APOC3 inhibition	10	Volanesorsen (investigational)

LDL-C = low-density lipoprotein C, SNP = single nucleotide polymorphism, TG = triglycerides.