Table 1. Genes that are regulated in the VTA of Clock mutant mice vs. wild-type littermate controls that may directly affect dopaminergic transmission or are known to be involved in circadian rhythms.
| Up-regulated | Down-regulated |
|---|---|
| Genes that may directly regulate dopaminergic transmission | |
| TH | Cholecystokinin |
| Synaptobrevin-like 1 | Potassium channel Q2 |
| NMDA receptor-regulated gene 1 | Preproenkephalin 1 |
| Glutamate receptor 1 | GABAA receptor β 1 |
| Glutamate receptor ionotropic kainate 5 γ 2 | |
| Glutamate receptor NMDA ζ 1 | |
| Synaptotagmin 5 | |
| Genes known to be involved in circadian rhythms | |
| Clock | Period 1 |
| Period 2 | |
| D site albumin promoter-binding protein | |
| Cryptochrome 2 | |
| Casein kinase 1 ε |