Table 1. Reelin promoter methylation summary.
| Methylated bases | NPS | SZP | P value |
|---|---|---|---|
| The Stanley Foundation | |||
| Upstream of RNA start site | 32.7 ± 4.9 | 40.8 ± 4.2 | 0.227 |
| Reelin promoter (–527–+322) | 50.8 ± 6.9 | 55.6 ± 5.7 | 0.598 |
| –370 | 0.2 ± 0.2 | 1.6 ± 0.3 | 0.002* |
| –139 | 0.4 ± 0.2 | 3.4 ± 0.5 | <0.001* |
| –134 | 0.3 ± 0.2 | 3.2 ± 0.5 | <0.001* |
| –58 | 2.1 ± 0.2 | 1.4 ± 0.3 | 0.052 |
| +21 | 0.9 ± 0.4 | 2.5 ± 0.4 | 0.012* |
| Harvard Brain Collection | |||
| Upstream of RNA start site | 51.0 ± 2.6 | 66.8 ± 1.5 | <0.001* |
| Reelin promoter (–527 to +322) | 71.4 ± 2.6 | 91.4 ± 3.2 | 0.001* |
| –330 | 2.8 ± 1.2 | 4.0 ± 0.8 | 0.436 |
| –302 | 2.6 ± 1.2 | 4.0 ± 0.8 | 0.358 |
| –222 | 2.6 ± 1.2 | 4.0 ± 0.8 | 0.358 |
| –200 | 2.6 ± 1.2 | 4.0 ± 0.8 | 0.358 |
| –139 | 0.8 ± 0.4 | 2.6 ± 0.5 | 0.021* |
| –134 | 0.8 ± 0.2 | 2.6 ± 0.5 | 0.011* |
| –109 | 2.6 ± 1.2 | 4.2 ± 0.9 | 0.302 |
| –96 | 2.6 ± 1.2 | 4.0 ± 0.8 | 0.358 |
| –83 | 2.6 ± 1.2 | 4.0 ± 0.8 | 0.358 |
| –58 | 2.2 ± 0.7 | 2.0 ± 0.5 | 0.822 |
| +21 | 0.6 ± 0.4 | 2.2 ± 0.4 | 0.019* |
| +145 | 2.4 ± 1.2 | 3.4 ± 1.0 | 0.538 |
Values are means ± SEM. The maximum at any single position is 6 for The Stanley Foundation specimens (n = 10 NSP and 10 SZP) and 8 for the Harvard Brain Collection specimens (n = 5 NSP and 5 SZP). P values were determined from a paired t test of the data by using the means and SEM between the two groups. *, P < 0.05.