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. 2005 Jun 20;102(26):9365–9370. doi: 10.1073/pnas.0503777102

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Copyright © 2005, The National Academy of Sciences

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Fig. 1. — PKA-dependent synaptic plasticity at corticoamygdala synapses. (A1) LTP elicited by 3 × 2 trains (*, 100 Hz, 1 s) was significantly reduced in the presence of the PKA inhibitor KT5720 (filled circles). (Insets) Sample traces 10 min before and 30 min after the tetanus. (Scale bars: 5 ms, 1 mV.) (A2) The PPF ratio (fEPSP2/fEPSP1) is significantly reduced 15 min after the induction of LTP in wild-type mice (Left). There is no significant change in the PPF ratio after the delivery of the LTP-induction protocol in the presence of KT5720 (Right). (B) LTP induced by a 20-Hz train (45 s) was significantly depressed in the presence of KT5720 (filled circles). (C) Amygdala LTP induced by 3 × 2 trains of tetanic stimulation (*) was significantly depressed when D-APV was present during the tetanic stimulation (filled circles). Open circles in A1, B, and C are control LTP.