Skip to main content
. 2005 Jun 16;102(26):9253–9257. doi: 10.1073/pnas.0503852102

Fig. 4.

Fig. 4.

Accelerated MCA-induced tumor development is caused by down-regulation of NKT cells. Jα281-/- mice were reconstituted with 2 × 105 α-GalCer/CD1d tetramer+ cells derived from naive wild-type BALB/c mice. MCA was inoculated 2 weeks before reconstitution. Immunization with plasmids encoding DnaJ-like 2 was performed at the time of reconstitution and subsequently repeated every 4 weeks. Mice, either reconstituted with α-GalCer/CD1d tetramer+ cells or not, and also immunized with DnaJ-like 2 or not, were monitored weekly for tumor development. The number of mice in each group is shown in parentheses. The arrows indicate days of cell transfer and immunization. % tumor frequency of each group at 10 weeks was compared with BALB/c mice receiving 50 μg of MCA alone by using Mann-Whitney U test (*, P < 0.001). These experiments were repeated three times with similar results.