Table 2. Demographic and clinical data of patients diagnosed with Plasmodium vivax malaria in Republic of Korea military hospitals, by study period.
| Variables | Years | P value | |||
|---|---|---|---|---|---|
| 2012–2016 (n = 408) | 2017–2021 (n = 245) | ||||
| Age, yr | 21.8 ± 3.4 | 22.2 ± 4.4 | 0.712 | ||
| Sex | |||||
| Male | 407 (99.8) | 245 (100.0) | > 0.999 | ||
| Female | 1 (0.2) | - | - | ||
| Body weight, kg | 72.9 ± 11.1 | 74.3 ± 10.3 | 0.044 | ||
| Time to diagnosis, days | 5 (3–7) | 4 (3–7) | 0.231 | ||
| PBS follow-up | 121 (29.7) | 89 (36.3) | 0.077 | ||
| Antimalarial treatment | |||||
| CQ administration | 408 (100.0) | 243 (99.2) | 0.140 | ||
| CQ base, total, mg | 1,476.0 ± 144.0 | 1,515.1 ± 155.1 | 0.010 | ||
| CQ base, total, mg/kg | 20.7 ± 3.6 | 20.7 ± 3.2 | 0.580 | ||
| CQ base < 25 mg/kg | 363 (89.0) | 226 (93.0) | 0.090 | ||
| PQ administration | 402 (98.5) | 245 (100) | 0.089 | ||
| PQ base, total, mg | 242.6 ± 79.7 | 265.7 ± 92.3 | < 0.001 | ||
| PQ base, total, mg/kg | 3.38 ± 1.1 | 3.64 ± 1.3 | 0.256 | ||
| PQ base < 3.5 mg/kg | 296 (73.6) | 167 (68.2) | 0.135 | ||
| Parasitemia at 72 hr after 1st CQ dose | 73/116 (62.9) | 49/80 (61.3) | 0.811 | ||
| Recurrence | 22 (5.4) | 7 (2.9) | 0.128 | ||
Values are presented as numbers (%), mean ± standard deviation, or median (interquartile range).
PBS = peripheral blood smear, CQ = chloroquine, PQ = primaquine.