Table 5.
Effect of thyroid stimulating hormone levels on DOR.
| Variables | Model 1 OR(95% CI) | Model 2 OR(95% CI) | Model 3 OR(95% CI) | Model 4 OR(95% CI) |
|---|---|---|---|---|
| TSH levels (µIU/mL) | ||||
| TSH<2.5 | Ref | Ref | Ref | |
| 2.5≤TSH≤4.2 | 1.329(0.957,1.846) | 1.332(0.958,1.851) | 1.310(0.936,1.832) | |
| SCH/OH | 1.745(1.134,2.686)* | 1.757(1.135,2.72)* | 1.819(1.158,2.858)* | |
| Thyroid autoimmunity | ||||
| TAI(-) | Ref | Ref | Ref | |
| TAI(+) | 1.045(0.715,1.528) | 0.965(0.656,1.419) | 0.902(0.609,1.336) | |
| Basic clinical characteristics | ||||
| Female age (years) | 1.219(1.164,1.277)* | |||
| BMI (kg/m2) | 1.025(0.974,1.08) | |||
| Duration of infertility (years) | 1.016(0.969,1.066) | |||
| Infertility type | ||||
| Primary infertility | Ref | |||
| Secondary infertility | 0.649(0.475,0.888)* | |||
Model 1: Univariate logistic regression analysis of TSH levels. Model 2: Univariate logistic regression analysis of TAI. Model 3: Adjusted for thyroid autoimmunity. Model 4: Model 3, with additional adjustments for female age, BMI, infertility duration, infertility type.
*P value<0.05.
DOR, diminished ovarian reserve; SCH/OH, Subclinical/overt hypothyroidism; TAI, thyroid autoimmunity.