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. 2024 Dec 10;11:1469275. doi: 10.3389/fmed.2024.1469275

Figure 7.

Figure 7

The mRNA expression level of myopia candidate genes in the retina after long or short-term treatment. Negative lens treatment significantly decreased retinal EGR-1 expression in room light (RL), in 10 Hz ON flicker (after 3 days), and in 10 Hz OFF flicker (after 7 days). Compared to the RL-LIM eyes, EGR-1 mRNA expression in the lens treated eyes was significantly higher, both in the 10-Hz ON and 10-Hz OFF stimuli, after 3 days. This effect persisted in the 10-ON group in the long-term experiment (A). A temporal effect was observed in the fellow eyes of the RL group, as the level of retinal EGR-1 mRNA decreased over time (A). After 3 days of treatment, the 10-Hz ON stimulus induced a significant increase in the level of retinal OPN4 mRNA in both eyes, compared to the RL and 10-OFF groups. However, after 7 days of treatment, this effect was observed only in the fellow eyes (B). The expression of retinal OPN5 mRNA was higher in LIM eyes in the 10-ON group than that in the 10-OFF group (C). In the short-term experiment, only the 10-OFF group showed an interocular effect in the expression of retinal GJD2 mRNA, which was an elevation in the LIM eyes (D). Data were shown as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001.