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. 2024 Dec 10;15:1491729. doi: 10.3389/fimmu.2024.1491729

Figure 1.

Figure 1

Hematopoiesis during homeostasis and in response to an inflammatory environment. Hematopoietic stem cells (Lin-cKit+ sca-1+ FIt3- CD150+CD48-) are at the top of hematopoiesis and switch from the quiescent state (qHSC) to the activated state (aHSC) to meet the demand for mature cells. They differentiate into multipotent cells (MPP), which have a preference for differentiating into a specific cell lineage. Thus, MPP2 (Lin- cKit+ sca-1+ FIt3- CD150+ CD48+) are oriented towards the erythro-megakaryocytic lineage, MPP3 (Lin- cKit+ sca-1+ Fit3- CD150- CD48+) towards the myeloid lineage and MPP4 (Lin- cKit+ sca-1+ Flt3+) towards the lymphoid lineage. MPP differentiate into the precursors of the MEP (Lin- cKit+ sca-1- CD16/32-CD34-), GMP (Lin- cKit+ sca-1- CD16/32+ CD34+) and CLP (Lin- cKit+ sca-1- FIt3+ IL7R+) lineages, which eventually give rise to mature cells. In response to inflammatory stimuli, HSCs are strongly activated and the myeloid differentiation pathway is mainly favored.