Table 4.

The relationship between serum cotinine and depression and sleep disorders in male participants.

		Model 1		Model 2
		OR (95%CI)	p	OR (95%CI)	p
Depression
	continuous	1.11 (1.07,1.15)	<0.001	1.05 (1.01,1.09)	0.014
	Q1	ref.		ref.
	Q2	1.20 (0.81,1.76)	0.351	1.13 (0.68,1.90)	0.623
	Q3	1.84 (1.31,2.58)	<0.001	1.07 (0.65,1.75)	0.799
	Q4	2.85 (2.00,4.07)	<0.001	1.68 (1.07,2.66)	0.027
	P for trend	<0.001		0.020
Trouble sleeping
	continuous	1.05 (1.02,1.07)	<0.001	1.04 (1.02,1.07)	<0.001
	Q1	ref.		ref.
	Q2	1.24 (1.00,1.53)	0.049	1.24 (1.00,1.54)	0.053
	Q3	1.61 (1.30,1.99)	<0.001	1.58 (1.26,1.99)	<0.001
	Q4	1.54 (1.24,1.92)	<0.001	1.58 (1.25,1.99)	<0.001
	P for trend	<0.001		<0.001
Diagnostic sleep disorder
	continuous	1.03 (0.99,1.06)	0.122	1.04 (1.00,1.07)	0.065
	Q1	ref.		ref.
	Q2	0.94 (0.71,1.26)	0.678	0.94 (0.70,1.26)	0.666
	Q3	1.15 (0.83,1.58)	0.394	1.15 (0.83,1.61)	0.388
	Q4	1.15 (0.82,1.61)	0.397	1.28 (0.92,1.79)	0.138
	P for trend	0.292		0.426

Model 1 was adjusted by age, race.

Model 2, for depression, was adjusted by FIPR, educational level, physical activity, alcohol drinking, diabetes, BMI levels, HEI-2015 and trouble sleeping; for trouble sleeping and diagnostic sleep disorder was adjusted by age, gender, race, FIPR, educational level, physical activity, alcohol drinking, diabetes, BMI levels, HEI-2015 and depression.