Table 6.
Risk factor analysis for graft dysfunction (defined as graft loss, an eGFR < 30 mL/min·1.73 m2 or an eGFR decline ≥ 50% of baseline)
| Risk factors for graft dysfunction | Unadjusted HR (95% CI) | p value | Adjusted HR (95% CI) | p value |
|---|---|---|---|---|
| Age at KTx, years | 0.97 (0.93–1.02) | 0.266 | ||
| Male sex | 1.14 (0.66–1.96) | 0.640 | ||
| > 1 KTx | 1.81 (0.91–3.58) | 0.092 | ||
| Living donation | 1.44 (0.84–2.48) | 0.189 | ||
| Donor age, years2 | 1.02 (1.01–1.04) | 0.005 | 1.02 (1.00–1.04) | 0.007 |
| Cold ischemia time | 0.98 (0.94–1.02) | 0.289 | ||
| HLA-DR mismatch (0 versus 1 or 2) | 1.09 (0.73–1.62) | 0.685 | ||
| Delayed graft function | 1.19 (0.48–2.99) | 0.710 | ||
| Time from dialysis to KTx (> 21 months) | 1.23 (0.72–2.09) | 0.447 | ||
| IL-2R antibody induction | 0.67 (0.38–1.17) | 0.161 | ||
| Potential recurrent disease1 | 1.14 (0.51–2.51) | 0.752 | ||
| BKPyV nephropathy2,3 | 5.45 (2.46–12.1) | < 0.001 | 7.20 (3.15–16.5) | < 0.001 |
| ABMR2,3 | 4.06 (2.13–7.73) | < 0.001 | 3.30 (1.72–6.33) | < 0.001 |
| TCMR and treated borderline rejection2,3 | 2.59 (1.52–4.42) | 0.001 | 2.48 (1.44–4.30) | 0.001 |
ABMR antibody-mediated rejection, BKPyV BK polyomavirus, CI confidence interval, HLA human leukocyte antigen, HR hazard ratio, IL-2R interleukin 2 receptor, KTx kidney transplantation, TCMR T cell-mediated rejection
1Potentional recurrent disease included: atypical hemolytic uremic syndrome, non-genetic focal segmental glomerulosclerosis, type I and type II membranoproliferative glomerulonephritis, IgA nephropathy, membranous glomerulonephritis, primary hyperoxaluria, and ANCA-associated vasculitis
2Multivariable Cox regression model with time-variable covariables adjusted for center effect
3Histopathologic diagnoses were treated as time-dependent variables